Molecular genetic features of pediatric gliomas
نویسندگان
چکیده
منابع مشابه
New strategies in pediatric gliomas: molecular advances in pediatric low-grade gliomas as a model.
Pediatric low-grade gliomas (pLGG) account for more brain tumors in children than any other histologic subtype. While surgery, chemotherapy and radiation remain the mainstay of upfront treatment, recent advances in molecular interrogation of pLGG have shown a small number of recurring genetic mutations in these tumors that might be exploited therapeutically. Notable findings include abnormaliti...
متن کاملIntegrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease.
PURPOSE To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). PATIENTS AND METHODS We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGGs, including seven diffuse intrinsic pontine gliomas, and 10 HGGs arising in children who received cranial irradiation for a previous cancer using single nucleotide p...
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We surveyed common genetic mutations (IDH1, H3F3A, PPM1D, and TP53) and immune features (PD-L1 expression and CD8+ T cell tumor infiltration) in a series of 62 malignant brainstem gliomas that were resected via microsurgery. IDH1 mutations were mutually exclusive with H3F3A mutations. IDH1 mutations appeared only in adults and occurred more frequently in tumors larger than 10cm3 (8/29 vs 1/32, ...
متن کاملCCR New Strategies New Strategies in Pediatric Gliomas: Molecular Advances in Pediatric Low-Grade Gliomas as a Model
Pediatric low-grade gliomas (pLGG) account formore brain tumors in children than any other histologic subtype. While surgery, chemotherapy and radiation remain the mainstay of upfront treatment, recent advances inmolecular interrogation of pLGGhave shown a small number of recurring genetic mutations in these tumors that might be exploited therapeutically. Notable findings include abnormalities ...
متن کاملMolecular Neuropathology of Gliomas
Gliomas are the most common primary human brain tumors. They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system. Over the past 20 years the cytogenetic and molecular genetic alterations associated with glioma formation and progression have been intense...
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ژورنال
عنوان ژورنال: Pediatric Hematology/Oncology and Immunopathology
سال: 2019
ISSN: 2414-9314,1726-1708
DOI: 10.24287/1726-1708-2019-18-4-109-117